Share-Based Expense (Tables)
|
12 Months Ended |
Dec. 31, 2021 |
|---|
| Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |
|
| Schedule of Share-Based Compensation Expense |
| Schedule of Share-Based Compensation Expense |
|
|
|
|
|
|
|
|
| |
|
Year Ended December 31, |
|
| |
|
2021 |
|
|
2020 |
|
| Research and development expenses |
|
$ |
68,208 |
|
|
$ |
49,190 |
|
| General and administrative expenses |
|
|
342,229 |
|
|
|
419,724 |
|
| |
|
$ |
410,437 |
|
|
$ |
468,914 |
|
|
| Assumptions used |
| Assumptions used |
|
|
|
|
|
|
|
|
| |
|
Year Ended December 31, |
|
| |
|
2021 |
|
|
2020 |
|
| Weighted-average expected dividend yield (%) |
|
|
– |
|
|
|
– |
|
| Weighted-average expected volatility (%) |
|
|
132.64 |
|
|
|
127.87 |
|
| Weighted-average risk-free interest rate (%) |
|
|
1.16 |
|
|
|
0.49 |
|
| Weighted-average expected life of option (years) |
|
|
5.73 |
|
|
|
5.50 |
|
| Weighted-average exercise price ($) |
|
|
2.15 |
|
|
|
1.10 |
|
|
| Schedule of option activity |
| Schedule of option activity |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| |
|
Number of
shares |
|
|
Weighted-
average
exercise
price |
|
|
Weighted-
average
remaining
life
(years) |
|
|
Aggregate
intrinsic
value |
|
| Outstanding as of January 1, 2020 |
|
|
662,059 |
|
|
$ |
10.88 |
|
|
|
9.34 |
|
|
$ |
66,125 |
|
| Granted |
|
|
125,000 |
|
|
|
1.10 |
|
|
|
|
|
|
|
|
|
| Expired |
|
|
(23,337 |
) |
|
|
52.55 |
|
|
|
|
|
|
|
|
|
| Outstanding as of December 31, 2020 |
|
|
763,722 |
|
|
|
8.01 |
|
|
|
8.68 |
|
|
$ |
498,625 |
|
| Granted |
|
|
325,000 |
|
|
|
2.15 |
|
|
|
|
|
|
|
|
|
| Expired |
|
|
– |
|
|
|
– |
|
|
|
|
|
|
|
|
|
| Outstanding as of December 31, 2021 |
|
|
1,088,722 |
|
|
$ |
6.26 |
|
|
|
8.22 |
|
|
$ |
23,750 |
|
| |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Vested or expected to vest as of December 31, 2021 |
|
|
1,088,722 |
|
|
$ |
6.26 |
|
|
|
8.22 |
|
|
$ |
23,750 |
|
| |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Exercisable as of December 31, 2020 |
|
|
372,042 |
|
|
$ |
15.12 |
|
|
|
8.09 |
|
|
$ |
186,449 |
|
| Exercisable as of December 31, 2021 |
|
|
630,357 |
|
|
$ |
9.42 |
|
|
|
7.63 |
|
|
$ |
23,750 |
|
|
| Non-vested option activity |
| Non-vested option activity |
|
|
|
|
|
|
|
|
| |
|
Number of
shares |
|
|
Weighted-
average
grant date
fair value |
|
| Balance as of January 1, 2021 |
|
|
391,680 |
|
|
$ |
1.15 |
|
| Granted |
|
|
325,000 |
|
|
$ |
1.93 |
|
| Forfeited |
|
|
– |
|
|
$ |
– |
|
| Vested |
|
|
(258,315 |
) |
|
$ |
1.11 |
|
| Balance as of December 31, 2021 |
|
|
458,365 |
|
|
$ |
1.73 |
|
|
| Common stock awards granted and issued |
| Common stock awards granted and issued |
|
|
|
|
| |
|
Number of shares |
|
| Balance as of January 1, 2020 |
|
|
8,594 |
|
| Granted |
|
|
– |
|
| Issued |
|
|
(1,188 |
) |
| Balance as of December 31, 2020 |
|
|
7,406 |
|
| Granted |
|
|
– |
|
| Issued |
|
|
(7,153 |
) |
| Balance as of December 31, 2021 |
|
|
253 |
|
|
| Non Employee Stock Options [Member] |
|
| Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |
|
| Schedule of option activity |
| Schedule of option activity |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| |
|
Number of
shares |
|
|
Weighted-
average
exercise
price |
|
|
Weighted-
average
remaining
life
(years) |
|
|
Aggregate
intrinsic
value |
|
| Outstanding as of January 1, 2020 |
|
|
20,560 |
|
|
$ |
17.09 |
|
|
|
4.74 |
|
|
$ |
– |
|
| Granted |
|
|
– |
|
|
|
– |
|
|
|
|
|
|
|
|
|
| Expired |
|
|
(242 |
) |
|
|
225.72 |
|
|
|
|
|
|
|
|
|
| Outstanding as of December 31, 2020 |
|
|
20,318 |
|
|
|
14.61 |
|
|
|
3.79 |
|
|
$ |
14,880 |
|
| Granted |
|
|
– |
|
|
|
– |
|
|
|
|
|
|
|
|
|
| Expired |
|
|
(243 |
) |
|
|
225.72 |
|
|
|
|
|
|
|
|
|
| Outstanding as of December 31, 2021 |
|
|
20,075 |
|
|
$ |
12.06 |
|
|
|
2.83 |
|
|
$ |
3,255 |
|
| |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Vested or expected to vest as of December 31, 2021 |
|
|
20,075 |
|
|
$ |
12.06 |
|
|
|
2.83 |
|
|
$ |
3,255 |
|
| |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Exercisable as of December 31, 2020 |
|
|
20,318 |
|
|
$ |
14.61 |
|
|
|
3.79 |
|
|
$ |
14,880 |
|
| Exercisable as of December 31, 2021 |
|
|
20,075 |
|
|
$ |
12.06 |
|
|
|
2.83 |
|
|
$ |
3,255 |
|
|