Annual report pursuant to Section 13 and 15(d)

CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY

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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($)
Preferred Stock [Member]
Common Stock [Member]
Additional Paid-in Capital [Member]
Retained Earnings [Member]
AOCI Attributable to Parent [Member]
Treasury Stock [Member]
Total
Beginning balance, value at Dec. 31, 2019 $ 2,774 $ 6,092 $ 188,240,451 $ (166,008,620) $ 253,734 $ (5,281,180) $ 17,213,251
Beginning balance, shares at Dec. 31, 2019 2,774,394 6,092,432          
Issuance of common stock in registered direct offering, net of issuance costs $ 2,499 5,424,376 5,426,825
Issuance of common stock in December 2020 registered direct offering, net of issuance costs, shares   2,448,980          
Exercise of purchase warrants $ 229 (229)
Exercise of purchase warrants, shares   229,598          
Issuance of common stock to vendor $ 1 (1)
Issuance of common stock to vendor, shares   1,188          
Share-based expense 468,914 468,914
Net loss (10,893,466) (10,893,466)
Ending balance, value at Dec. 31, 2020 $ 2,774 $ 8,771 194,133,511 (176,902,086) 253,734 (5,281,180) 12,215,524
Ending balance, shares at Dec. 31, 2020 2,774,394 8,772,198          
Issuance of common stock and warrants, net of issuance costs $ 950 11,449,916 11,450,866
Issuance of common stock and warrants, net of issuance costs, shares   950,000          
Exercise of pre-funded warrants $ 3,679 3,679
Exercise of pre-funded warrants, shares   3,679,630          
Exercise of purchase warrants $ 6 (6)
Exercise of purchase warrants, shares   5,988          
Issuance of common stock to vendor $ 7 (7)
Issuance of common stock to vendor, shares   7,153          
Issuance of common stock in connection with warrant buyout $ 52 (41,122) (41,070)
Issuance of common stock in connection with warrant buyout, shares   51,634          
Share-based expense 410,437 410,437
Net loss (5,645,179) (5,645,179)
Ending balance, value at Dec. 31, 2021 $ 2,774 $ 13,465 $ 205,952,729 $ (182,547,265) $ 253,734 $ (5,281,180) $ 18,394,257
Ending balance, shares at Dec. 31, 2021 2,774,394 13,466,603