Annual report pursuant to Section 13 and 15(d)

12. Share-Based Compensation (Details - Employee option activity)

v3.7.0.1
12. Share-Based Compensation (Details - Employee option activity) - Employee Stock Options [Member] - USD ($)
 12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Options outstanding, beginning balance 619,259 126,862
Options granted 603,622 493,945
Options exercised 0 0
Options expired (29,169) (1,548)
Options outstanding, ending balance 1,193,712 619,259
Options vested or expected to vest 1,193,712  
Options exercisable 440,092 239,819
Weighted-average exercise price outstanding, beginning balance $ 15.22 $ 20.53
Weighted-average exercise price, granted 3.49 13.86
Weighted-average exercise price, expired 12.38 15.51
Weighted-average exercise price, ending balance 4.43 15.22
Weighted-average exercise price, vested or expected to vest 4.43  
Weighted-average exercise price, exercisable $ 5.60 $ 17.17
Weighted-average remaining life outstanding 8 years 11 months 9 days 8 years 11 months 1 day
Weighted-average remaining life, vested or expected to vest 8 years 11 months 9 days  
Weighted-average remaining life, exercisable 8 years 11 months 9 days 7 years 9 months 11 days
Aggregate intrinsic value, outstanding beginning balance $ 1,915,942  
Aggregate intrinsic value, exercised   $ 509,622
Aggregate intrinsic value, outstanding ending balance 526,073 1,915,942
Aggregate intrinsic value, vested or expected to vest 526,073  
Aggregate intrinsic value, exercisable $ 55,109 $ 688,343