Annual report pursuant to Section 13 and 15(d)

Stockholders' Equity - Additional Information (Detail)

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Stockholders' Equity - Additional Information (Detail)
 12 Months Ended
Dec. 31, 2012
USD ($)
shares
Dec. 31, 2011
USD ($)
Tranches
shares
Dec. 31, 2010
shares
Dec. 31, 2013
USD ($)
shares
Minimum [Member] | Tranches One [Member] | Serum Institute [Member]        
Schedule Of Stockholders Equity [Line Items]        
Warrants expiration date   Dec. 31, 2012    
Warrants issued   800,000    
Minimum [Member] | Tranches Two [Member] | Serum Institute [Member]        
Schedule Of Stockholders Equity [Line Items]        
Warrants issued   800,000    
Minimum [Member] | Tranches Three [Member] | Serum Institute [Member]        
Schedule Of Stockholders Equity [Line Items]        
Warrants issued   800,000    
Minimum [Member] | Serum Institute [Member]        
Schedule Of Stockholders Equity [Line Items]        
Warrants expiration period   6 months    
Number of tranches | Tranches   3    
Maximum [Member] | Serum Institute [Member]        
Schedule Of Stockholders Equity [Line Items]        
Warrants expiration period   18 months    
Baxter Healthcare [Member]        
Schedule Of Stockholders Equity [Line Items]        
Warrants granted to purchase common stock     4,588,298  
Warrants expiration date     Jun. 30, 2015  
Warrants outstanding | $ $ 932,000     $ 932,000
Syn Bio [Member]        
Schedule Of Stockholders Equity [Line Items]        
Warrants granted to purchase common stock   3,545,600    
Warrants expiration date   Dec. 02, 2016    
Warrants outstanding | $ $ 108,000     $ 108,000
Warrants exercise holding period   2 years    
Serum Institute [Member]        
Schedule Of Stockholders Equity [Line Items]        
Warrants granted to purchase common stock   2,400,000    
Warrants outstanding | $   $ 10,000    
Warrants expired during the period 800,000      
Warrants granted to purchase common stock, shares 1,600,000      
Warrants issued 0     0