Quarterly report pursuant to Section 13 or 15(d)

8. Share-Based Compensation (Details Narrative)

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8. Share-Based Compensation (Details Narrative) - USD ($)
3 Months Ended 9 Months Ended
Sep. 30, 2017
Sep. 30, 2016
Sep. 30, 2017
Sep. 30, 2016
Dec. 31, 2016
Share based compensation $ 301,991 $ 616,933 $ 1,491,855 $ 2,635,196  
(Gain) loss related to warrant issuances $ (22,000) (2,000) $ (100,000) $ 1,100,000  
Warrants issued     0 212,222  
Warrant [Member] | Collaboration Agreements [Member]          
Warrants outstanding 646,249   646,249   646,249
Employee Stock Options [Member]          
Options granted     350,000 12,122  
Share based compensation $ 300,000 500,000 $ 1,400,000 $ 1,300,000  
Incremental compensation expense from exercise extension date     $ 4,000 $ 24,000  
Non Employee Stock Options [Member]          
Options granted     0 0  
Share based compensation $ 8,000 60,000 $ 80,000 $ 60,000  
Incremental compensation expense from exercise extension date   $ 17,000      
Common Stock Awards [Member]          
Common stock grants 14,091 8,146 26,801 20,309  
Share based compensation $ 38,000 $ 37,000 $ 100,000 $ 100,000