Annual report pursuant to Section 13 and 15(d)

12. Share-Based Compensation (Details - Share based compensation)

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12. Share-Based Compensation (Details - Share based compensation) - USD ($)
12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Share-based compensation $ 2,594,113 $ 1,513,238
Research and Development Expense [Member]    
Share-based compensation 229,964 952,829
General and Administrative Expense [Member]    
Share-based compensation $ 2,364,149 $ 560,409