Annual report pursuant to Section 13 and 15(d)

12. Share-Based Expense (Details - Share based expense)

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12. Share-Based Expense (Details - Share based expense) - USD ($)
12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Share-based compensation $ 468,914 $ 853,517
Research and Development Expense [Member]    
Share-based compensation 49,190 126,933
General and Administrative Expense [Member]    
Share-based compensation $ 419,724 $ 726,584