Quarterly report pursuant to Section 13 or 15(d)

8. Share-Based Compensation (Details Narrative)

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8. Share-Based Compensation (Details Narrative) - USD ($)
3 Months Ended 9 Months Ended
Sep. 30, 2018
Sep. 30, 2017
Sep. 30, 2018
Sep. 30, 2017
Dec. 31, 2017
Share based compensation $ 323,478 $ 301,991 $ 1,175,281 $ 1,491,855  
Warrants outstanding 3,152,225   3,152,225    
Warrant [Member] | Collaboration Agreements [Member]          
Warrants outstanding 539,202   539,202   646,249
Fair value adjustment of warrants $ 39,000 22,000 $ (25,000) $ 100,000  
Warrants issued     0 0  
Warrants exercised     0 0  
Employee Stock Options [Member]          
Options granted     0 350,000  
Options exercised     0 0  
Risk free interest rate       0.19%  
Expected volatility       110.00%  
Share based compensation 300,000 300,000 $ 1,100,000 $ 1,400,000  
Incremental compensation expense from exercise extension date       $ 4,000  
Non Employee Stock Options [Member]          
Options granted     10,000 0  
Options exercised     0 0  
Risk free interest rate     1.70%    
Expected volatility     118.10%    
Share based compensation $ 1,000 $ 8,000 $ 36,000 $ 80,000  
Common Stock Awards [Member]          
Other than options granted 4,477 14,091 19,495 26,801  
Share based compensation $ 17,000 $ 38,000 $ 52,000 $ 100,000