Annual report pursuant to Section 13 and 15(d)

11. Share-Based Expense (Details - Share based expense)

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11. Share-Based Expense (Details - Share based expense) - USD ($)
12 Months Ended
Dec. 31, 2019
Dec. 31, 2018
Share-based compensation $ 853,517 $ 1,431,787
Research and Development Expense [Member]    
Share-based compensation 126,933 203,030
General and Administrative Expense [Member]    
Share-based compensation $ 726,584 $ 1,228,757