Annual report pursuant to Section 13 and 15(d)

11. Share-Based Expense (Tables)

v3.20.1
11. Share-Based Expense (Tables)
12 Months Ended
Dec. 31, 2019
Schedule of Share-Based Compensation Expense
    Year Ended December 31,  
    2019     2018  
Research and development expenses   $ 126,933     $ 203,030  
General and administrative expenses     726,584       1,228,757  
    $ 853,517     $ 1,431,787  
Common Stock Awards [Member]  
Common stock awards
    Number of shares  
Balance as of January 1, 2018     5,237  
Granted     2,167  
Issued      
Balance as of December 31, 2018     7,404  
Granted     9,026  
Issued     (7,836
Balance as of December 31, 2019     8,594  
Employee Stock Options [Member]  
Assumptions used
    Year Ended December 31,  
    2019     2018  
Weighted-average expected dividend yield (%)            
Weighted-average expected volatility (%)     156.78       118.03  
Weighted-average risk-free interest rate (%)     1.71       2.90  
Weighted-average expected life of option (years)     5.88       5.90  
Weighted-average exercise price ($)     1.31       36.60  
Option activity
    Number of
shares
    Weighted-
average
exercise
price
    Weighted-
average
remaining
life
(years)
    Aggregate
intrinsic
value
 
Outstanding as of January 1, 2018     148,381     $ 47.90       8.53     $ 5,273  
Granted     8,336       36.60                  
Expired     (9,245 )     68.76                  
Outstanding as of December 31, 2018     147,472       45.95       8.17     $  
Granted     525,000       1.31                  
Expired     (10,413 )     25.32                  
Outstanding as of December 31, 2019     662,059     $ 10.88       9.34     $ 66,125  
                                 
Vested or expected to vest as of December 31, 2019     662,059     $ 10.88       9.34     $ 66,125  
                                 
Exercisable as of December 31, 2018     96,031     $ 49.34       7.92     $  
Exercisable as of December 31, 2019     123,864     $ 47.69       7.10     $  
Non-vested option activity
    Number of
shares
    Weighted-
average
grant date
fair value
 
Balance as of January 1, 2019     51,439     $ 31.92  
Granted     525,000     $ 1.24  
Forfeited     (10,413 )   $ 14.44  
Vested     (27,831 )   $ 37.37  
Balance as of December 31, 2019     538,195     $ 2.05  
Non Employee Stock Options [Member]  
Option activity
    Number of
shares
    Weighted-
average
exercise
price
    Weighted-
average
remaining
life
(years)
    Aggregate
intrinsic
value
 
Outstanding as of January 1, 2018     4,731     $ 90.49       6.31     $  
Granted     834       23.16                  
Expired     (263 )     219.00                  
Outstanding as of December 31, 2018     5,302       73.52       5.40     $  
Granted     15,500       1.08                  
Expired     (242 )     225.72                  
Outstanding as of December 31, 2019     20,560     $ 17.09       4.74     $  
                                 
Vested or expected to vest as of December 31, 2019     20,560     $ 17.09       4.74     $  
                                 
Exercisable as of December 31, 2018     5,302     $ 73.52       5.40     $  
Exercisable as of December 31, 2019     5,060     $ 66.15       4.63     $  
Non-vested option activity
    Number of
shares
    Weighted-
average
grant date
fair value
 
Balance as of January 1, 2019         $  
Granted     15,500     $ 0.94  
Vested         $  
Balance as of December 31, 2019     15,500     $ 0.94