10. Share-Based Expense (Details - Share based expense) - USD ($) |
3 Months Ended | 12 Months Ended | ||
|---|---|---|---|---|
Mar. 31, 2019 |
Mar. 31, 2018 |
Dec. 31, 2018 |
Dec. 31, 2017 |
|
| Share-based compensation | $ 233,940 | $ 406,194 | $ 1,431,787 | $ 1,793,093 |
| Research and Development Expense [Member] | ||||
| Share-based compensation | 11,418 | 60,345 | 203,030 | 101,401 |
| General and Administrative Expense [Member] | ||||
| Share-based compensation | $ 222,522 | $ 345,849 | $ 1,228,757 | $ 1,691,692 |
| X | ||||||||||
- Definition Amount of expense for award under share-based payment arrangement. Excludes amount capitalized. Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
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| X | ||||||||||
- Details
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| X | ||||||||||
- Details
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