General form of registration statement for all companies including face-amount certificate companies

10. Share-Based Expense (Tables)

10. Share-Based Expense (Tables)

3 Months Ended

12 Months Ended

Mar. 31, 2019

Dec. 31, 2018

Schedule of Share-Based Compensation Expense

		Three Months Ended March 31,
		2019				2018
Research and development expenses		$	11,418			$	60,345
General and administrative expenses			222,522				345,849
		$	233,940			$	406,194

		Year Ended December 31,
		2018				2017
Research and development expenses		$	203,030			$	101,401
General and administrative expenses			1,228,757				1,691,692
		$	1,431,787			$	1,793,093

Common Stock Awards [Member]

Common stock awards

		Number of shares
Balance as of January 1, 2017			2,483
Granted			3,484
Issued			(732	)
Balance as of December 31, 2017			5,235
Granted			2,167
Issued			–
Balance as of December 31, 2018			7.402

Employee Stock Options [Member]

Assumptions used

		Year Ended December 31,
		2018				2017
Weighted-average expected dividend yield (%)			–				–
Weighted-average expected volatility (%)			118.03				111.37
Weighted-average risk-free interest rate (%)			2.90				1.79
Weighted-average expected life of option (years)			5.90				5.36
Weighted-average exercise price ($)			36.60				40.08

Option activity

		Number of shares				Weighted- average exercise price				Weighted- average remaining life (years)				Aggregate intrinsic value
Outstanding as of January 1, 2017			99,476			$	53.16				8.94			$	526,073
Granted			58,334				40.08
Expired			(9,446	)			55.32
Outstanding as of December 31, 2017			148,364				47.88				8.53			$	5,273
Granted			8,334				36.60
Expired			(9,245	)			68.76
Outstanding as of December 31, 2018			147,453			$	45.96				8.17			$	–

Vested or expected to vest as of December 31, 2018			145,370			$	46.20				8.16			$	–

Exercisable as of December 31, 2017			60,992			$	58.08				7.44			$	5,273
Exercisable as of December 31, 2018			96,015			$	49.32				7.92			$	–

Non-vested option activity

		Number of shares				Weighted- average grant date fair value
Balance as of January 1, 2018			87,373			$	34.32
Granted			8,334			$	31.56
Forfeited			(556	)		$	34.92
Vested			(43,712	)		$	36.60
Balance as of December 31, 2018			51,439			$	31.80

Non Employee Stock Options [Member]

Option activity

		Number of shares				Weighted- average exercise price				Weighted- average remaining life (years)				Aggregate intrinsic value
Outstanding as of January 1, 2017			4,787			$	90.84				7.23			$	–
Expired			(61	)			124.08
Outstanding as of December 31, 2017			4,726				90.36				6.31			$	–
Granted			834				23.16
Expired			(263	)			219
Outstanding as of December 31, 2018			5,297			$	73.44				5.40			$	–

Vested or expected to vest as of December 31, 2018			5,297			$	73.44				5.40			$	–

Exercisable as of December 31, 2017			4,727			$	90.36				6.31			$	–
Exercisable as of December 31, 2018			5,297			$	73.44				5.40			$	–

Non-vested option activity

		Number of shares				Weighted- average grant date fair value
Balance as of January 1, 2018			–			$	–
Granted			834			$	20.76
Vested			(834	)		$	20.76
Balance as of December 31, 2018			–			$	–