Quarterly report pursuant to Section 13 or 15(d)

7. Share-Based Compensation (Details Narrative)

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7. Share-Based Compensation (Details Narrative) - USD ($)
3 Months Ended 6 Months Ended
Jun. 30, 2018
Jun. 30, 2017
Jun. 30, 2018
Jun. 30, 2017
Dec. 31, 2017
Share based compensation $ 445,609 $ 523,868 $ 851,803 $ 1,189,864  
Warrants outstanding 3,152,225   3,152,225    
Warrant [Member] | Collaboration Agreements [Member]          
Warrants outstanding 646,249   646,249   649,249
Fair value adjustment of warrants $ 59,000 (80,000) $ 64,000 $ (100,000)  
Warrants issued     0 0  
Warrants exercised     0 0  
Employee Stock Options [Member]          
Options granted     0 350,000  
Options exercised     0 0  
Risk free interest rate       0.19%  
Expected volatility       110.00%  
Share based compensation 300,000 500,000 $ 700,000 $ 1,100,000  
Incremental compensation expense from exercise extension date       $ 4,000  
Non Employee Stock Options [Member]          
Options granted     10,000 0  
Options exercised     0 0  
Risk free interest rate     1.70%    
Expected volatility     118.10%    
Share based compensation $ 26,000 $ 30,000 $ 35,000 $ 70,000  
Common Stock Awards [Member]          
Other than options granted 6,924 7,235 15,018 12,710  
Share based compensation $ 17,000 $ 30,000 $ 35,000 $ 60,000