Annual report pursuant to Section 13 and 15(d)

12. Share-Based Compensation (Details - Employee option activity)

v3.8.0.1
12. Share-Based Compensation (Details - Employee option activity) - Employee Stock Options [Member] - USD ($)
 12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Options outstanding, beginning balance 1,193,712 619,259
Options granted 700,000 603,622
Options expired (113,343) (29,169)
Options outstanding, ending balance 1,780,369 1,193,712
Options vested or expected to vest 1,755,369  
Options exercisable 731,895 440,092
Weighted-average exercise price outstanding, beginning balance $ 4.43 $ 15.22
Weighted-average exercise price, granted 3.34 3.49
Weighted-average exercise price, expired 4.61 12.38
Weighted-average exercise price, ending balance 3.99 4.43
Weighted-average exercise price, vested or expected to vest 4.02  
Weighted-average exercise price, exercisable $ 4.84 $ 5.6
Weighted-average remaining life outstanding 8 years 6 months 11 days 8 years 11 months 1 day
Weighted-average remaining life, vested or expected to vest 8 years 6 months 4 days  
Weighted-average remaining life, exercisable 7 years 5 months 8 days 8 years 11 months 8 days
Aggregate intrinsic value, outstanding beginning balance $ 526,073 $ 1,915,942
Aggregate intrinsic value, outstanding ending balance 5,273 526,073
Aggregate intrinsic value, vested or expected to vest 5,273  
Aggregate intrinsic value, exercisable $ 5,273 $ 55,109