Annual report pursuant to Section 13 and 15(d)

10. Income Taxes (Details - Tax reconcilation)

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10. Income Taxes (Details - Tax reconcilation) - USD ($)
12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Income Tax Disclosure [Abstract]    
Federal $ (1,222,345) $ (18,429,763)
State (303,315) (455,191)
Increase in tax losses not recognized (359,833) 9,751,401
Permanent differences, net 162,543 780,836
Mark to market 0 992,621
Foreign rate differential (383,601) 6,923,116
Share-based payments, net (22,087) 524,131
Changes per enacted tax reform 2,320,059 0
Enhanced research and development tax credits (191,421) (87,151)
Net provision (benefit) for income taxes $ 0 $ 0