Quarterly report pursuant to Section 13 or 15(d)

9. Share-Based Expense (Details Narrative)

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9. Share-Based Expense (Details Narrative) - USD ($)
3 Months Ended 9 Months Ended
Sep. 30, 2019
Sep. 30, 2018
Sep. 30, 2019
Sep. 30, 2018
Dec. 31, 2018
Share based compensation $ 247,437 $ 323,478 $ 730,531 $ 1,175,281  
Warrant [Member] | Collaboration Agreements [Member]          
Warrants outstanding 44,944   44,944   44,944
Weighted average exercise price $ 124.90   $ 124.90    
Warrants issued     0 0  
Warrants exercised     0 0  
Warrants expiration dates     December 2019 through May 2021    
Employee Stock Options [Member]          
Options granted     0 0  
Options exercised     0 0  
Share based compensation $ 200,000 300,000 $ 700,000 $ 1,100,000  
Non Employee Stock Options [Member]          
Options granted     0 834  
Options exercised     0 0  
Share based compensation $ 0 $ 1,000 $ 0 $ 36,000  
Common Stock Awards [Member]          
Other than options granted 7,153 375 9,026 1,627  
Share based compensation $ 15,000 $ 17,000 $ 47,000 $ 52,000