Quarterly report pursuant to Section 13 or 15(d)

8. Share-Based Compensation (Details Narrative)

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8. Share-Based Compensation (Details Narrative) - USD ($)
3 Months Ended 6 Months Ended
Jun. 30, 2017
Jun. 30, 2016
Jun. 30, 2017
Jun. 30, 2016
Dec. 31, 2016
Share based compensation $ 523,868 $ 1,731,803 $ 1,189,864 $ 2,018,263  
Fair value adjustment of warrants     $ 95,906 $ (1,118,642)  
Warrants issued     0 212,222  
Warrant [Member] | Collaboration Agreements [Member]          
Warrants outstanding 646,249   646,249   646,249
Employee Stock Options [Member]          
Options granted     350,000 12,122  
Share based compensation $ 500,000 300,000 $ 1,100,000 $ 800,000  
Incremental compensation expense from exercise extension date     $ 4,000 $ 24,000  
Non Employee Stock Options [Member]          
Options granted     0 0  
Share based compensation $ 30,000 $ 3,000 $ 70,000 $ 3,000  
Common Stock Awards [Member]          
Common stock grants 7,235 9,581 12,710 11,939  
Share based compensation $ 30,000 $ 50,000 $ 60,000 $ 100,000