Annual report pursuant to Section 13 and 15(d)

Share-Based Expense (Details - Non-Vested employee Option activity)

v3.23.1
Share-Based Expense (Details - Non-Vested employee Option activity) - Research, development, license and supply agreement [Member]
 12 Months Ended
Dec. 31, 2022
$ / shares
shares
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]  
Non-vested options outstanding, beginning balance | shares 458,365
Non-vested weighted-average grant date fair value per share, beginning balance | $ / shares $ 1.73
Options granted | shares 350,000
Weighted-average grant date fair value per share, options granted | $ / shares $ 0.73
Options forfeited | shares 0
Weighted-average grant date fair value per share, options forfeited | $ / shares $ 0
Options vested | shares (375,027)
Weighted-average grant date fair value per share, options vested | $ / shares $ 1.59
Non-vested options outstanding, ending balance | shares 433,338
Non-vested weighted-average grant date fair value per share, ending balance | $ / shares $ 1.04