Registration of securities issued in business combination transactions

10. Share-Based Compensation (Details - Non-employee option activity)

v3.19.1
10. Share-Based Compensation (Details - Non-employee option activity) - Non Employee Stock Options [Member] - USD ($)
 3 Months Ended 12 Months Ended
Mar. 31, 2019
Mar. 31, 2018
Dec. 31, 2018
Dec. 31, 2017
Options outstanding, beginning balance 63,571 56,719 56,719 57,442
Options granted 0 10,000 10,000 0
Options expired     (3,148) (723)
Options outstanding, ending balance     63,571 56,719
Options vested or expected to vest     63,571  
Weighted-average exercise price outstanding, beginning balance $ 6.12 $ 7.53 $ 7.53 $ 7.57
Weighted-average exercise price, granted     1.93  
Weighted-average exercise price, forfeited/expired     18.25 10.34
Weighted-average exercise price, ending balance     6.12 7.53
Weighted-average exercise price, vested or expected to vest     6.12  
Weighted-average exercise price, exercisable     $ 6.12 $ 7.53
Weighted-average remaining life outstanding     5 years 4 months 24 days 6 years 3 months 22 days
Weighted-average remaining life, vested or expected to vest     5 years 4 months 24 days  
Weighted-average remaining life, exercisable     5 years 4 months 24 days 6 years 3 months 22 days
Aggregate intrinsic value, outstanding beginning balance $ 0 $ 0 $ 0 $ 0
Aggregate intrinsic value, outstanding ending balance     0 0
Aggregate intrinsic value, vested or expected to vest     0  
Aggregate intrinsic value, exercisable     $ 0 $ 0