October 31, 2016

VIA EDGAR AND E-MAIL

United States Securities and Exchange Commission
Attention:          Suzanne Hayes, Assistant Director, Office of Healthcare and Insurance

Division of Corporation Finance
100 F Street, N.E.
Washington, D.C. 20549-6010

Ladies and Gentlemen:

In accordance with Rule 461 of Regulation C of the General Rules and Regulations under the Securities Act of 1933, as amended, we hereby request acceleration of the effective date of the Registration Statement on Form S-1 (File No. 333-211249) (the “Registration Statement”) of Xenetic Biosciences, Inc. (the “Company”). We respectfully request that the Registration Statement become effective as of 4:00 p.m., Eastern Daylight Time, on November 1, 2016, or as soon as practicable thereafter. Once the Registration Statement has been declared effective, please orally confirm that event with our counsel, Taft Stettinius & Hollister LLP, by calling Mitchell D. Goldsmith at (312) 836-4006.

Thank you for your assistance in this matter.